bispecific antibodies การใช้

• In April 2009, the bispecific antibody catumaxomab was approved in the European Union.
• Recently, the bispecific antibodies, a novel class of therapeutic antibodies, have yielded promising results in clinical trials.
• Genentech was able to demonstrate in mouse models that the new bispecific antibody was able to reach therapeutic levels in the brain.
• All of these formats can be composed from variable fragments with specificity for two different antigens, in which case they are types of bispecific antibodies.
• In-vitro and in-vivo activity of CIK cells in conjunction with bispecific antibodies, cross-linking cytotoxic effector cells with malignant targets, was enhanced compared with CIK cells alone.
• Another way of immunotherapeutic intervention strategies is the exploration of bispecific antibodies with different structures, of which bi-specific T-cell engagers ( BiTEs ) have been produced since the mid-2000s.
• Other types of bispecific antibodies have been designed to overcome certain problems, such as short bivalent and trivalent single-chain variable fragments ( scFvs ), fusion proteins mimicking the variable domains of two antibodies.
• Researchers at Genentech proposed the creation of a bispecific antibody that could bind the BBB membrane, induce receptor-mediated transcytosis, and release itself on the other side into the brain and CNS . They utilized a mouse bispecific antibody with two active sites performing different functions.
• Researchers at Genentech proposed the creation of a bispecific antibody that could bind the BBB membrane, induce receptor-mediated transcytosis, and release itself on the other side into the brain and CNS . They utilized a mouse bispecific antibody with two active sites performing different functions.